Lack of linkage between idiopathic generalized epilepsies and the gene encoding the neural cell adhesion molecule
β Scribed by Thomas Sander; Thomas Hildmann; Dieter Janz; Amedeo Bianchi; Gerhard Bauer; Alejandro Scaramelli; Gertrud Beck-Mannagetta
- Book ID
- 103932493
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 534 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0920-1211
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Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). The pivotal function of ionotropic gamma-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system suggests that they may be involved in epilepto
The gene encoding the GABA B receptor (GABA B R1) maps close to the HLA-F locus on chromosome 6p21.3 in the same region to which a major susceptibility locus for common subtypes of idiopathic generalized epilepsy (IGE), designated as EJM1, has been localized. Moreover, animal models suggest that the