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Linkage analysis between idiopathic generalized epilepsies and the GABAA receptor α5, β3 and γ3 subunit gene cluster on chromosome 15

✍ Scribed by T. Sander; R. Kretz; M. P. Williamson; F. V. Elmslie; M. Rees; T. Hildmann; A. Bianchi; G. Bauer; U. Sailer; A. Scaramelli; B. Schmitz; R. M. Gardiner; D. Janz; G. Beck-Mannagetta

Book ID: 109335644
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 732 KB
Volume: 96
Category: Article
ISSN: 0001-6314
DOI: 10.1111/j.1600-0404.1997.tb00230.x

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Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). The pivotal function of ionotropic gamma-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system suggests that they may be involved in epilepto