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Lack of leu-3a epitope on t-helper (cd4) lymphocytes

✍ Scribed by Channabasappa V. Angadi

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 211 KB
Volume: 4
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860040309

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✦ Synopsis

Abstract

Human T‐helper cells express membrane‐bound CD4 antigen whose many epitopes are recognized by different monoclonal antibodies. The epitope recognized by Leu‐3a and similar clones has been shown to be the location for human immunodeficiency virus (HIV) receptor. We have found a unique blood donor whose CD4^+^ T‐helper lymphocytes were lacking Leu‐3a epitope. CD4^+^ T‐helper cells lacking Leu‐3a epitope might be resistant to HIV infection.

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