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A novel CD4+ T-helper lymphocyte epitope in the VP3 protein of hepatitis A virus

✍ Scribed by Glòria Sánchez; Rosa M. Pintó; Albert Bosch

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
328 KB
Volume
72
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Prediction analysis of T~H~‐cell epitopes in the VP3 capsid protein of the hepatitis A virus (HAV) revealed the occurrence of a putative T~H~ epitope in the 102–121 region complying with all the algorithms tested. To confirm these predictions, spleen T lymphocytes obtained from BALB/c mice previously immunised with HAV, were stimulated in vitro with different concentrations of synthetic peptides 102–121 and 110–121 of VP3. The ability of these peptides to stimulate CD4^+^ T‐helper lymphocytes proliferation was evaluated by an immunological flow cytometry detection of bromodeoxyuridine incorporation. Using this method, it is concluded that the amino terminal part of the VP3 102–121 sequence contains a T cell epitope. J. Med. Virol. 72:525–532, 2004. © 2004 Wiley‐Liss, Inc.

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