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Lack of in vivo activation of the interferon system in HBsAg-positive chronic active hepatitis

โœ Scribed by Alain Poitrine; Suzanne Chousterman; Michel Chousterman; Sylvie Naveau; Ming Nguy Thang; Jean-Claude Chaput

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
391 KB
Volume
5
Category
Article
ISSN
0270-9139

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โœฆ Synopsis

The in uivo activation state of the interferon system was biochemically evaluated in patients with HBsAg-positive liver disease by assaying the interferon-induced enzyme, 2 '5 ' -01igoadenylate synthetase, in peripheral blood mononuclear cells. All patients with chronic active hepatitis had normal levels of enzyme activity. Increased values were found in 77% of patients with acute hepatitis, 50% of those with chronic persistent hepatitis and 54% chronic healthy carriers. These results provide evidence for lack of activation of the interferon system in HBsAg-positive chronic active hepatitis and support the hypothesis that an in vivo defective interferon response may aid in development of chronic active hepatitis.

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