Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans
β Scribed by A. Vella; P. Shah; A. S. Reed; A. S. Adkins; R. Basu; R. A. Rizza
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 82 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0012-186X
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## Background: The insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1), regulate insulin secretion to nutrient intake and constitute the endocrine arm of the entero-insular axis. glucagon has been implicated in the pathophysio
Insulin-like eects of glucagon-like peptide-1(7-36)amide (GLP-1) in rat liver, skeletal muscle and fat, and also the presence of GLP-1 receptors in these extrapancreatic tissues, have been documented. In skeletal muscle and liver, the action of GLP-1 is not associated with an activation of adenylate
GLP-1, an incretin hormone of the enteroinsular axis with insulinotropic and glucagonostatic activity, is secreted after nutrient ingestion. GLP-1 is mainly produced by intestinal L-cells in the lower gastrointestinal tract (GIT); simple carbohydrates are absorbed in the upper GIT and β£-glucosidase