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Continuous stimulation of human glucagon-like peptide-1 (7–36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes

✍ Scribed by J. Zhang; Y. Tokui; K. Yamagata; J. Kozawa; K. Sayama; H. Iwahashi; K. Okita; M. Miuchi; H. Konya; T. Hamaguchi; M. Namba; I. Shimomura; J-i. Miyagawa


Publisher
Springer
Year
2007
Tongue
English
Weight
311 KB
Volume
50
Category
Article
ISSN
0012-186X

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Prolonged and enhanced secretion of gluc
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GLP-1, an incretin hormone of the enteroinsular axis with insulinotropic and glucagonostatic activity, is secreted after nutrient ingestion. GLP-1 is mainly produced by intestinal L-cells in the lower gastrointestinal tract (GIT); simple carbohydrates are absorbed in the upper GIT and ␣-glucosidase