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Lack of association of single nucleotide polymorphism inLRCH1with knee osteoarthritis susceptibility

✍ Scribed by Qing Jiang; Dongquan Shi; Masahiro Nakajima; Jin Dai; Jia Wei; Konstantinos N. Malizos; Jianghui Qin; Yoshinari Miyamoto; Naoyuki Kamatani; Baorui Liu; Aspasia Tsezou; Takahiro Nakamura; Shiro Ikegawa


Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
164 KB
Volume
53
Category
Article
ISSN
1435-232X

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## Abstract ## Objective To perform a large‐scale association analysis of single‐nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee. ## Methods We examined >25,000 SNPs located within ∼14,000 genes for associations with radiographically defi

Association of KLOTHO gene polymorphisms
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## Abstract Based on the fact that klotho‐deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that __KLOTHO__ gene plays an important role in calcium/phosphate homeostasis, we explored the possibility whether human