Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes
✍ Scribed by Patricia Gassó; Sergi Mas; Anna Crescenti; Santi Álvarez; Gemma Parramon; Clemente Garcia-Rizo; Eduard Parellada; Miquel Bernardo; Amalia Lafuente
- Book ID
- 116849900
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 123 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0165-1781
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Potential contributions of dopamine transporter (DAT) gene variants to delusional disorder were investigated using association analysis. DAT gene VNTR polymorphisms were assessed in 61 delusional patients and 54 normal controls. No differences were found in either genotypic or allelic distributions.
## Abstract DRD~1~ and DRD~2~ receptor gene variants have been associated with clinical aspects of schizophrenia; however only specific features were analyzed in different samples. To assess the complex interaction between genetic and clinical factors, we studied the possible cross‐interactions bet