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Lack of adalimumab's complement dependent cytotoxicity on human cells expressing complement regulatory proteins

โœ Scribed by K M Grebe, J Salfeld, Z Kaymakcalan

Book ID
120690506
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
119 KB
Volume
8
Category
Article
ISSN
1479-5876

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Complement regulatory proteins present on the surface of various mammalian cells play an important role in controlling homologous lysis, by interacting with C3 (and usually C4). These proteins have a similar structural motif ("short consensus repeat") (Reid, K.B.