Labetalol in the treatment of epinephrine overdose

✍ Scribed by L Scott Larsen; Anna Larsen

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 295 KB
• Volume: 19
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(05)82478-3

✦ Synopsis

CASE REPORT epinephrine, overdose; labetalol

Labetalol in the Treatment of Epinephrine Overdose

A 31-year-old man being treated for asthma accidently received 3 mg SQ epinephrine. He began retching and vomiting and developed agitation and profuse diaphoresis. He was treated with 5 mg IV labetalol. His symptoms improved significantly, and he required no further treatment. Although he felt a transient increase in his respiratory effort shortly after administration of the drug, he did not develop wheezing or require additional therapy for bronchospasm. The B-blocking effect of labetalol is greater than the antagonism. The patient exhibited evidence of mild a stimulation due to incomplete blockade. This is consistent with previous studies in that labetalol tends to less completely antagonize the ~ effects of a mixed ~/~ agonist, resulting in a net clinical picture of mild ~ agonism. [