✦ LIBER ✦

Potential of liquid membranes for drug overdose treatment: In vitro studies

✍ Scribed by Chia-Whei Chiang; George C. Fuller; John W. Frankenfeld; C. T. Rhodes

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 355 KB
Volume: 67
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600670117

No coin nor oath required. For personal study only.

✦ Synopsis

The in vitro removal of six barbiturates from pH 2 donor solutions by liquid membranes with pH control was evaluated. More than 90% of amorbarbital, phenobarbital, and secobarbital were removed within 10 min by the liquid membranes. Drug transport obeyed first-order kinetics initially, and Fick's law was obeyed. The transport rate of phenobarbital by a liquid membrane was temperature dependent. An Arrhenius plot revealed that the activation energy was 10 kcal/mole. The liquid membranes showed some instability in the presence of bile salts.

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