Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitrothiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitrothiophene-2-carboxamide and 5-nitrothiophen
Labelled compounds of interest as antitumour agents I: N-methylformamide and N, N-dimethylformamide
✍ Scribed by Michael D Threadgill; E Nicholas Gate
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 189 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Efficient preparations of N‐methylformamide (an active antitumour agent) have been developed in which the compound is labelled with ^14^C in the formyl group, with ^14^C in the methyl group and with deuterium in the methyl group. N, N‐Dimethyl‐^14^C‐formamide has also been synthesised.
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