𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Labelled compounds of interest as antitumour agents I: N-methylformamide and N, N-dimethylformamide

✍ Scribed by Michael D Threadgill; E Nicholas Gate


Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
189 KB
Volume
20
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

Efficient preparations of N‐methylformamide (an active antitumour agent) have been developed in which the compound is labelled with ^14^C in the formyl group, with ^14^C in the methyl group and with deuterium in the methyl group. N, N‐Dimethyl‐^14^C‐formamide has also been synthesised.


📜 SIMILAR VOLUMES


Labelled compounds of interest as antitu
✍ Anne E. Shinkwin; Michael D. Threadgill 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB 👁 2 views

Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitrothiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitrothiophene-2-carboxamide and 5-nitrothiophen

Labelled compounds of interest as antitu
✍ Martin Scobie; Sean P. Bew; Michael D. Threadgill 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 275 KB 👁 1 views

## Abstract Quenching the anion generated from a 2‐(ω‐carboranylalkyl)dithiane with ^2^H~2~O at −78°C and at 0°C introduced deuterium exclusively at C‐2 of the carborane. Extension of this model reaction to a bioreductively‐targetted carborane allowed the synthesis of 2‐[^2^H]‐ and 2‐[^3^H]‐isotopo

Labelled compounds of interest as antitu
✍ Sandra Ferrer; Declan P. Naughton; Michael D. Threadgill 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB

## Abstract Treatment of 2‐chloro‐4,6‐(dimethylamino)‐1,3,5‐triazine with trideuteromethylamine gave 4,6‐(dimethylamino)‐2‐trideuteromethyl‐1,3,5‐triazine, an isotopomer of the experimental anticancer agent pentamethylmelamine (PMM). Mitsunobu coupling with 1,2‐dimethyl‐3‐hydroxymethyl‐5‐methoxy‐in

Labelled compounds of interest as antitu
✍ Paul Webb; Michael D. Threadgill 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 265 KB

## Abstract Chemically and radiochemically efficient syntheses of N‐(2‐hydroxy‐2‐[^2^H]ethyl)‐2‐(2‐nitroimidazol‐l‐yl)acetamide and N‐(2‐hydroxy‐2‐[^3^H]ethyl)‐2‐(2‐nitroimidazol‐1‐yl)acetamide, isotopomers of the hypoxic cell radiosensitiser etanidazole (SR 2508), have been achieved by reduction o