✦ LIBER ✦
Labelled compounds of interest as antitumour agents. Part 41. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT
✍ Scribed by Martin Scobie; Sean P. Bew; Michael D. Threadgill
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 275 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Quenching the anion generated from a 2‐(ω‐carboranylalkyl)dithiane with ^2^H~2~O at −78°C and at 0°C introduced deuterium exclusively at C‐2 of the carborane. Extension of this model reaction to a bioreductively‐targetted carborane allowed the synthesis of 2‐[^2^H]‐ and 2‐[^3^H]‐isotopomers of a nitroimidazole‐carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.