Labeling of A1 adenosine receptors in porcine atria with the antagonist radioligand 8-cyclopentyl-1,3-[3H]dipropylxanthine
β Scribed by Mark Leid; Paul H. Franklin; Thomas F. Murray
- Book ID
- 115881847
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 282 KB
- Volume
- 147
- Category
- Article
- ISSN
- 0014-2999
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## 8-Cy~lopentyl-l,3-[~H] dipropylxanthine (['HICPX ) is a potent radioligand that specifically binds to the A l adenosine receptors. Its high specificity makes it a suitable ligand for the characterization of A l adenosine receptors in tissues with low receptor densities. We have demonstrated tha
The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro