8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) — a selective high affinity antagonist radioligand for A1adenosine receptors
✍ Scribed by Martin J. Lohse; Karl-Norbert Klotz; Jutta Lindenborn-Fotinos; Martin Reddington; Ulrich Schwabe; Ray A. Olsson
- Book ID
- 112274922
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 772 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0028-1298
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The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro