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Labeled steroids of potential biological interest: Synthesis and properties of 180-labeled 17 α-hydroperoxypro-gesterone

✍ Scribed by Pierre Falardeau; Liat Tan

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
355 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^18^Oxygen labeled 17α‐hydroperoxyprogesterone has been synthesized via a 3‐step reaction sequence in an all‐glass, high vacuum transfer system. The hydroperoxidation reaction was found to proceed smoothly only, when an adequate oxygen pressure in the reaction vessel is maintained. Comparisons are made between the mass spectral fragmentations of the ordinary ^16^O, and the isotopically labeled ^18^0–17α‐hydroperoxyprogesterones. Their NMR‐spectra display a splitting of the 18‐, and 31‐methyl signals, probably due to the coexistence of two finite conformations of the acetyl side‐chain.

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