✦ LIBER ✦
[D-Ala2, Phe (p-NO2)4, Leu5]Enkephalin Amide and Nα-[D-Ala2, Leu5]-Enkephalyl-Nε-Acetyl-Lysine Amide: Synthesis and Biological Properties of Prospective Enkephalin Cooperative-Affinity and Photoaffinity Labels. Preliminary communication
✍ Scribed by José V. Castell; Alex N. Eberle; V. Marly Kriwaczek; Aung Tun-Kyi; Peter W. Schiller; Kim Quang Do; Peter Thanei; Robert Schwyzer
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- German
- Weight
- 275 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
As a study preliminary to attempts at photoaffinity and cooperative affinity labelling of cells and cell membrane vesicles bearing opiate receptors, the title compounds were prepared and tested by rat brain membrane binding assays and by a modified guinea‐pig ileum bio‐assay. The potency of the two compounds in both systems was considerably greater than that of the standard peptide, [Leu^5^]enkephalin, justifying further work with these and similar compounds.