𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Labeled aryl fluorides from the nucleophilic displacement of activated nitro groups by 18F-F−

✍ Scribed by Marina Attiná; Fulvio Cacace; Alfred P. Wolf

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
496 KB
Volume
20
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Nucleophilic displacement of activated nitro groups by ^18^F‐fluoride ion is an efficient route to fluorine‐18 labeled aromatics, which can be obtained in the no‐carrier‐added state if required.

The basic features of the fluorodenitration process are comparatively evaluated, and the influence of the experimental variables on its course are discussed. Examples concerning the preparation of typical ^18^F‐labeled aromatic molecules are reported.

📜 SIMILAR VOLUMES

Nucleophilic [18F]Fluorination and subse
Nucleophilic [18F]Fluorination and subsequent decarbonylation of methoxy-substituted nitro- and halogen-benzenes activated by one or two formyl groups
✍ Bin Shen; Dirk Löffler; Gerald Reischl; Hans-Jürgen Machulla; Klaus-Peter Zeller 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

## Abstract As model reactions for the introduction of ^18^F into protected aromatic amino acids, the replacement of NO~2~, Cl, Br and F by [^18^F]fluoride in 2‐isophthalaldehyde and 2‐terephthalaldehyde derivatives which model ^18^F‐DOPA and ^18^F‐tyrosine was investigated by comparing labelling y