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Labdane diterpenes with a new oxidation pattern from the marine pulmonate Trimusculus peruvianus

✍ Scribed by Ana R Dı́az-Marrero; Enrique Dorta; Mercedes Cueto; Juana Rovirosa; Aurelio San-Martı́n; Alberto Loyola; José Darias

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
127 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

Four new labdane diterpenes, 1-4, with an unusual oxidation pattern have been isolated from the marine pulmonate Trimusculus peruvianus. The structure and stereochemistry of these compounds were determined by spectroscopic data and chemical transformations. The absolute stereochemistry of 4 was assigned by application of the modified Mosher method. These compounds exhibit in vitro moderate cytotoxic activity against human colon carcinoma cell lines.

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