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L003 Lack of association between the α-adducin locus and essential hypertension in the Japanese population

✍ Scribed by N. Kato; T. Sugiyama; T. Nabika; H. Morita; H. Kurihara; Y. Yazaki; Y. Yamori

Book ID: 117604578
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 137 KB
Volume: 11
Category: Article
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)91426-6

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## Background: The substitution of tryptophan for glycine at amino acid 460 (gly460trp polymorphism) of the alpha-subunit of the heterodimeric cytoskeleton protein adducin increases renal sodium reabsorption and may be involved in the pathophysiology of essential hypertension. in the present study,