Enantiomerically pure L-erythroand L-threo-4-fluoroglutamic acids la and lb were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the
L-Threo- and L-erythro-3-fluoroglutamic acids. Synthesis by fluorodehydroxylation and enzymic resolution
β Scribed by Vidal-Cros, Anne; Gaudry, Michel; Marquet, Andree
- Book ID
- 126782303
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 614 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-3263
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Abrrracr . Stereospecific syntheses of (+)-L-rlrreo and (-)-D-eryrhro-4-fluoroglutamic acid am based on the hydrolysis of methyl l-acetyl-4-fluoro-L-pyrroklin-5-one-2-carboxylate, prepared from rrans-and cis-4hydmxyproliues, respectively. After the discovery of the antimetabolic properties of fluoro