L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats
✍ Scribed by Nathan A. Davies; Gavin Wright; Lars M. Ytrebø; Vanessa Stadlbauer; Ole-Martin Fuskevåg; Claudia Zwingmann; D. Ceri Davies; Abeba Habtesion; Stephen J. Hodges; Rajiv Jalan
- Book ID
- 102238975
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 347 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0270-9139
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📜 SIMILAR VOLUMES
Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing g
NOTE. Amino acids were measured in CSF samples obtained via indwelling cisterna magna catheters at coma stages of encephalopathy in 6 ALF rats treated with saline infusions versus 6 ALF rats treated with OA (330 mg/kg/h) at equivalent time points. \*Values significantly different from saline-treate