L-Ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure
✍ Scribed by Christopher Rose; Adrianna Michalak; K. V. Rao; Günter Quack; Gerald Kircheis; Roger F. Butterworth
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 100 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
NOTE. Amino acids were measured in CSF samples obtained via indwelling cisterna magna catheters at coma stages of encephalopathy in 6 ALF rats treated with saline infusions versus 6 ALF rats treated with OA (330 mg/kg/h) at equivalent time points.
*Values significantly different from saline-treated controls, P Ͻ .01 by Student' s t test. TABLE 4. Muscle Glutamine Synthetase Activity in Saline Versus OA-Treated Rats Treatment Group Muscle Glutamine Synthetase Activity (mol/mg prot/h) Saline 0.21 Ϯ 0.03 (6) OA 0.39 Ϯ 0.04 (7)* NOTE. Values represent the mean Ϯ SD of duplicate determinations. Number of animals per treatment group in parentheses. *Values significantly different from saline-treated group, P Ͻ .01 by Student' s t test.