l-Lysine production in continuous culture of anl-lysine hyperproducing mutant ofCorynebacterium glutamicum

✍ Scribed by Toshihiko Hirao; Tetsuo Nakano; Tomoki Azuma; Masahiro Sugimoto; Toshihide Nakanishi

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 389 KB
• Volume: 32
• Category: Article
• ISSN: 1432-0614
• DOI: 10.1007/bf00184972

✦ Synopsis

L-Lysine production was studied in continuous culture with a single-stage cultivation process using the L-lysine hyperproducing mutant B-6 of Corynebacterium glutamicum. Strain B-6 showed stable L-lysine production for over 500 h. The maximum values of L-lysine-HC1 concentration and volumetric productivity were 105 g/1 and 5.6 g/1 per hour, respectively. The latter corresponded to a 2.5-fold higher value than that of a fed-batch culture. Higher agitation or use of oxygen-enriched air was critical for high productivity. This indicates that oxygen supply greatly affects L-lysine productivity in continuous culture.