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l-DOPA induces Ca2+-dependent and tetrodotoxin-sensitive release of endogenous glutamate from rat striatal slices

✍ Scribed by Yoshio Goshima; Kaoru Ohno; Shinichi Nakamura; Takeaki Miyamae; Yoshimi Misu; Akinori Akaike

Book ID
115803900
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
333 KB
Volume
617
Category
Article
ISSN
0006-8993

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✍ G. Lonart; K. L. Cassels; Dr. K. M. Johnson πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 505 KB

## Abstract Hydroxylamine (0.01–30 mM), a nitric oxide (NO) generator, produced a concentration‐dependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 ΞΌM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 ΞΌM)‐stimulated [^3^H]DA efflux.