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Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor

✍ Scribed by Jaen, Juan C.; Laborde, Edgardo; Bucsh, Ruth A.; Caprathe, Bradley W.; Sorenson, Roderick J.; Fergus, James; Spiegel, Katharyn; Marks, James; Dickerson, Melvin R.; Davis, Robert E.

Book ID: 115485327
Publisher: American Chemical Society
Year: 1995
Tongue: English
Weight: 995 KB
Volume: 38
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00022a008

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## Abstract Recent evidence has established a role for p75^NGFR^ in developmentally regulated neuronal cell death. Although cell death due to NGF withdrawal is a well described, apoptosis in sympathetic neurons through stimulation of p75^NGFR^ has not been clearly demonstrated. We have found that a