Ciliary neurotrophic factor enhances the expression of NGF and p75 low-affinity NGF receptor in astrocytes
β Scribed by Irina Semkova; Josef Krieglstein
- Book ID
- 114005162
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 721 KB
- Volume
- 838
- Category
- Article
- ISSN
- 0006-8993
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In the central nervous system (CNS), p75, or lowaffinity nerve growth factor receptor (LNGFR), is assumed to play a critical role in mediating the effects of neurotrophins on neuronal survival. Recent studies have shown that nerve growth factor (NGF) can act also on immune cells through its binding
## Abstract Nerve growth factor (NGF) and its lowβaffinity receptor, p75 neurotrophin receptor (p75NTR), are important mediators of pain. To explore further the mechanisms involved, we examined suppression of pain behavior and expression of neuropeptides such as calcitonin geneβrelated peptide (CGR
## Abstract Recent evidence has established a role for p75^NGFR^ in developmentally regulated neuronal cell death. Although cell death due to NGF withdrawal is a well described, apoptosis in sympathetic neurons through stimulation of p75^NGFR^ has not been clearly demonstrated. We have found that a