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Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

✍ Scribed by GHALEB, Amr M; NANDAN, Mandayam O; CHANCHEVALAP, Sengthong; DALTON, W Brian; HISAMUDDIN, Irfan M; YANG, Vincent W


Book ID
110020616
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
112 KB
Volume
15
Category
Article
ISSN
0007-0610

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The diverse functions of Krüppel-like fa
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## Abstract The Krüppel‐like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes including proliferation, differentiation, development and apoptosis. KLF4 and KLF5 are two closely related members of this family a

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An essential role for the Kru ¨ppel-like transcription factor family has been determined in the regulation of remarkable processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death. A member of this group, Kru ¨ppel-like factor 6 (KLF6), identified on th

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## Abstract The Sp/KLF family contains at least twenty identified members which include Sp1‐4 and numerous krüppel‐like factors. Members of the family bind with varying affinities to sequences designated as ‘Sp1 sites’ (e.g., GC‐boxes, CACCC‐boxes, and basic transcription elements). Family members