𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of Krüppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells

✍ Scribed by Bin Zheng; Mei Han; Jin-Kun Wen

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
246 KB
Volume
62
Category
Article
ISSN
1521-6543

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel‐like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs. © 2010 IUBMB IUBMB Life, 62(2): 132–139, 2010

📜 SIMILAR VOLUMES

Biology of Krüppel-like factor 6 transcr
Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death
✍ Verónica Andreoli; Ricardo C. Gehrau; Jose Luis Bocco 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

An essential role for the Kru ¨ppel-like transcription factor family has been determined in the regulation of remarkable processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death. A member of this group, Kru ¨ppel-like factor 6 (KLF6), identified on th

Sp1 and krüppel-like factor family of tr
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer
✍ Adrian R. Black; Jennifer D. Black; Jane Azizkhan-Clifford 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract The Sp/KLF family contains at least twenty identified members which include Sp1‐4 and numerous krüppel‐like factors. Members of the family bind with varying affinities to sequences designated as ‘Sp1 sites’ (e.g., GC‐boxes, CACCC‐boxes, and basic transcription elements). Family members

The diverse functions of Krüppel-like fa
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology
✍ Beth B. McConnell; Amr M. Ghaleb; Mandayam O. Nandan; Vincent W. Yang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

## Abstract The Krüppel‐like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes including proliferation, differentiation, development and apoptosis. KLF4 and KLF5 are two closely related members of this family a

Expression of vascular endothelial growt
Expression of vascular endothelial growth factor receptors in smooth muscle cells
✍ Atsushi Ishida; Jacqueline Murray; Yuji Saito; Chryso Kanthou; Omar Benzakour; M 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 329 KB 👁 1 views

Vascular Endothelial Growth Factor (VEGF) has been typically considered to be an endothelial-specific growth factor. However, it was recently demonstrated that VEGF can interact with non endothelial cells. In this study, we tested whether vascular smooth muscles cells (VSMCs) can express VEGF recept

The effects of peptides with estrogen-li
The effects of peptides with estrogen-like activity on cell proliferation and energy metabolism in human derived vascular smooth muscle cells
✍ D. Somjen; E. Knoll; B. Gayer; R. Kasher; F. Kohen; N. Stern 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

Hormone replacement therapy (HRT) for post-menopausal symptoms in diabetes is associated with increased risk of coronary heart disease and stroke. Therefore, there is a need for new HRT with no adverse effects on diabetic post-menopausal women. We developed peptides as potential estrogen mimetic com

Identification and characterization of t
Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells
✍ Rebecca Thill; William B. Campbell; Carol L. Williams 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB

## Abstract The guanine nucleotide exchange factor (GEF), SmgGDS, promotes nucleotide exchange by several GTPases in both the Ras and Rho families, especially by RhoA. Because RhoA plays an important role in regulating the contraction of vascular smooth muscle cells (VSMC), we examined the expressi