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KRAS mutational status assessment in patients with metastatic colorectal cancer: are the clinical implications so clear?

✍ Scribed by M. HEBBAR; P. FOURNIER; O. ROMANO


Book ID
108710814
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
73 KB
Volume
19
Category
Article
ISSN
0961-5423

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✍ Daniel J. Freeman; Todd Juan; Maureen Reiner; J. Randolph Hecht; Neal J. Meropol πŸ“‚ Article πŸ“… 2008 πŸ› CIG Media Group, LP. 🌐 English βš– 502 KB

Background: Identifying predictive biomarkers is important to optimally treat patients. This analysis evaluated the association of K-ras, BRAF, and PIK3CA gene mutations with tumor resistance to panitumumab alone. Patients and Methods: From 3 phase II panitumumab metastatic colorectal cancer (mCRC)