Konformationsanalysen von Modell-Tripeptiden: Der Einfluss von α,α-disubstituierten α-Aminosäuren auf die Sekundärstruktur. Teil I. NMR- und CD-Untersuchungen

✍ Scribed by Peter Wipf; Heinz Heimgartner

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: German
• Volume: 71
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19880710129

✦ Synopsis

190, CH-8057 Zurich (2.XI.87) Conformational Analysis of Tripeptide Models: The Influence of a,adisubstitnted a-Amino Acids on the Secondary Structure. NMR and CD Investigations

The conformational properties of a,a -disubstituted a-amino acids are discussed on the basis of NMR, CD, X-ray, and molecular-mechanics studies on tripeptide models 1. It is shown that different disubstituted amino acids do not exert the same influence on secondary-structure formation. Thus, the choice of substituents allows the construction and stabilisation of different conformations of oligopeptide chains.