Konformationsanalysen von Modell-Tripeptiden: Der Einfluss von α,α-disubstituierten α-Aminosäuren auf die Sekundärstruktur. Teil II. Röntgenstrukturanalyse und Konformationsenergie-Berechnungen
✍ Scribed by Peter Wipf; Roland W. Kunz; Roland Prewo; Heinz Heimgartner
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- German
- Weight
- 338 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Conformational Analysis of Tripeptide Models: The Influence of a,a-disubstituted a-Amino Acids on the Secondary Structure. X-Ray Analysis and Conformational Energy Calculations
The X-ray analysis of tripeptide Z-Ile-Val(2-Me)-benzocaine (If) reveals the presence of a type-I11 ,?-turn. Moreover, MMP2 calculations on tripeptides, e. g . Z-Ile-Aib-benzocaine (lc), Z-Ile-D-Val(2-Me)-benzocaine (lg), Z-Ile-Gly(2,2-Pr2)-benzocaine (lh), Z-Ile-Gly-benzocaine (la), and lf, fit well into the frame of NMR and CD investigations. They allow considerations on the relative stability of different types of 8-turns dependig on the peptide sequence, e.g. the kind of cc,a -disubstituted amino-acid moieties.