Klinefelter's syndrome and extragonadal germ cell tumors
β Scribed by Martin W. Lee; Ronald L. Stephens
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 359 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Germ cell neoplasms are uncommon. Most are of gonadal origin with only a small proportion developing in extragonadal sites. Recently we saw primary mediastinal germinomas in brothers.
Klinefelter's syndrome is a genetic disorder of male sexual differentiation characterized by an XXY karyotype. Although considered a benign condition, it is associated with several types of malignancies, including mediastinal germ-cell neoplasm. In addition, Klinefelter's syndrome has been rarely as
In patients with primary germ cell tumors, treatment with combination chemotherapy followed by surgical debulking of residual tissue usually produces favorable results. The best treatment for patients with extragonadal germ cell tumors ( E m ) remains a problem. In our series of 12 patients, importa
A retrospective analysis was performed on all patients diagnosed with biopsyproven extragonadal germ cell tumors at the University of Virginia (Charlottesville, VA), The Medical University of South Carolina (Charleston, SC), the Bethesda Naval Hospital (Bethesda, MD), and The Medical College of Virg