KIT exon 11 deletion–inversions represent complex mutations in gastrointestinal stromal tumors
✍ Scribed by Jerzy Lasota; Markku Miettinen
- Book ID
- 113513098
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 125 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Gastrointestinal stromal tumors are mesenchymal tumors arising in the stomach and small bowel and more rarely in the rectum, esophagus, peritoneum and retroperitoneum. These tumors are characterized by __KIT__ or __PDGFRA__ mutations. __KIT__ mutations are all in frame and lead to const
## Abstract Gastrointestinal stromal tumors (GISTs) are a specific and rare subset of human gastrointestinal tract tumors. Most GISTs show gain‐of‐function mutations of __KIT__, mainly in exon 11, that always maintain the reading frame. We report on data from a 43‐year‐old Japanese man with recurre