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Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors

โœ Scribed by Lasota, Jerzy; vel Dobosz, Anna Jerzak; Wasag, Bartosz; Wozniak, Agnieszka; Kraszewska, Ewa; Michej, Wanda; Ptaszynski, Konrad; Rutkowski, Piotr; Sarlomo-Rikala, Maarit; Steigen, Sonja E


Book ID
109886179
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
293 KB
Volume
87
Category
Article
ISSN
0023-6837

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Gastrointestinal stromal tumors (GISTs) typically express high levels of the Kit-receptor. The majority of GISTs carry mutations in the c-kit protooncogene clustering in exon 11. The significance of c-kit mutations for the biological behavior of GISTs is still under discussion. We evaluated 55 spora