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Kinetoplastid RNA editing: complexes and catalysts

✍ Scribed by Kenneth Stuart; Thomas E Allen; Moffett L Kable; Sobomabo Lawson

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 797 KB
Volume: 1
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(97)80071-3

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✦ Synopsis

RNA editing in kinetoplastids involves post-transcriptional insertion and deletion of uridylates (Us) to produce mature mitochondrial mRNAs with sequences specified by trans acting small guide RNAs. In vitro studies indicate the reaction pathway involves endonucleolytic cleavage of the precursor mRNA at the editing site, uridylate addition or removal at the 3' end of the 5' cleavage product, followed by ligation to the 3' cleavage product. This editing is catalyzed by a macromolecular complex that is in the early stages of characterization. Recent studies have resolved the general mechanism of editing, and show that editing occurs in association with a macromolecular complex.

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