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Kinetics of131I-o-Iodohippurate in rats

✍ Scribed by Tomáš Trnovec; Mária Gregušková; Štefan Bezek; Vasil Koprda

Book ID: 104682465
Publisher: Springer
Year: 1978
Tongue: English
Weight: 245 KB
Volume: 3
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00251403

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✦ Synopsis

The organ distribution of 131I-o-iodohippurate (OIH) was studied in rats in the time interval of 1--1440 min. The mean decrease of OIH in plasma was fitted with a function composed of three exponential terms. A three-compartment model describing kinetics of OIH in rats was suggested and its parameters were computed. Comparison of organ and plasma concentrations of OIH showed that the liver, up to 30 min, and the heart and lungs, up to 15 min after administration, form with plasma a common central compartment.

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