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Kinetics of sulfamethylthiadiazole acetylation and excretion in humans

โœ Scribed by Eino Nelson; Inge O'Reilly

Publisher
John Wiley and Sons
Year
1961
Tongue
English
Weight
333 KB
Volume
50
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

In studying the postabsorptive and postequilibrative phases of sulfamethylthiadiazole excretion and acetylation in humans, it was found that urinary excretion of unchanged drug and its acetylation could be described by competitive first-order p c e s s e s . The excretion of acetylated drug was also by a first-order process that ollowed its first-order acetylation. The mean half-life for excretion of unchanged drug was about one and one-half hours, for formation of acetylated drug about fifteen hours, and for excretion of acetylated drug about one-half hour. Experimental values of excretion were in excellent agreement with values predicted by equations previously developed to describe the kinetic model found to hold in the present work.

T WAS RECENTLY reported that the acetylation

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