The pharmacokinetic disposition of methazolamide (MTZ) was studied in five healthy volunteers following administration of a single oral dose. Drug concentrations in blood, plasma, and urine were measured by HPLC. Over the range of plasma concentrations observed in vivo, MTZ free fraction (measured b
✦ LIBER ✦
Sulfamethylthiadiazole: Human Blood Concentration and Urinary Excretion Data Following Oral Doses
✍ Scribed by Robinson, Manford J. ;Bondi, Amedeo ;Swintosky, Joseph V.
- Publisher
- Elsevier
- Year
- 1958
- Weight
- 450 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0095-9553
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## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini