𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Kinetics of Subcellular Distribution of Compounds in Simple Biosystems and its Use in QSAR

✍ Scribed by R. Dvorsky; S. Balaz; R.J. Sawchuk

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
436 KB
Volume
185
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

✦ Synopsis

An explicit expression describing the kinetics of distribution and, in some cases, biological activity in drugs and other anthropogenic chemicals in a four-compartment system consisting of a catenary chain of alternating aqueous and lipoid phases is derived. Substitution of the transport rate parameters by their appropriate relations to the reference partition coefficient converts the kinetic equations into the quantitative structure-time-activity relationship (QSTAR) or its fixed-time equivalent, QSAR. The resulting expression describes satisfactorily the published data on antibacterial activity of n-alkyl amines as a function of their hydrophobicity. The hydrophobicity-activity profile consists of two or three smoothly connected linear parts. The model can be used in drug design, pharmacokinetics, and toxicology for description of the distribution of compounds in simple biosystems and in environmental sciences to predict the fate and effects of anthropogenic chemicals in ecological systems.

πŸ“œ SIMILAR VOLUMES

Kinetics of Subcellular Distribution of
Kinetics of Subcellular Distribution of Multiply Ionizable Compounds: A Mathematical Description and its Use in QSAR
✍ Ε  tefan Bal Γ‘ ΕΎ; K. Pir Ε‘elov Γ‘; T.W. Schultz; J. Hermens πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 507 KB

An explicit mathematical model describing the distribution and, in some cases, also biological activity of anthropogenic chemicals capable of multiple ionization in biological systems during the elimination period has been constructed. The biological system is represented by a catenary chain of alte

A propranolol radioimmunoassay and its u
A propranolol radioimmunoassay and its use in the study of its pharmaco-kinetics following low doses
✍ G. P. Mould; J. Clough; B. A. Morris; G. Stout; V. Marks πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 462 KB

## Abstract A radioimmunoassay has been developed for propranolol with a sensitivity of 2.37nmol l^βˆ’1^ in unextracted plasma using a 50 ΞΌl sample. Plasma concentration measurements were made on samples from volunteers for up to 8 h after they had been given 5, 10, or 40 mg of propranolol by mouth.

Polymerization kinetics of styrene by ol
Polymerization kinetics of styrene by oligododecandioyl peroxide, and its use in the preparation of graft copolymers
✍ Baki Hazer; Aysel Kurt πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 279 KB

Bulk polymerization of styrene with oligododecandioyl peroxide (ODDP) was studied and the overall rate constant, k, was found as 8.4. lo-' at 60Β°C and 5.1 I 10e4 (l/mol)'~\*sec-' at 80Β°C. Active polystyrene containing peroxy groups (0.93 wt%) was obtained by the polymerization of styrene with ODDP a

The Ξ² subunit of the guanine nucleotide
The Ξ² subunit of the guanine nucleotide regulatory proteins: Identification of its location on two-dimesional gels of brain tissue and its regional and subcellular distribution in brain
✍ W.E. Heydorn; P. Gierschik; G.J. Creed; G. Milligan; A. Spiegel; D.M. Jacobowitz πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 783 KB

The @ subunit of the guanine nucleotide regulatory proteins (also termed G proteins) has been examined in both rat and human brain. Proteins contained within samples of fresh rat and human brain tissue were separated by twodimensional gel electrophoresis and either stained with silver or reacted wit