Kinetics of polymorphic transformation of sulfathiazole form I

✍ Scribed by Elie G. Shami; Peter D. Bernardo; Elisabeth S. Rattei; Louis J. Ravin

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 227 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610834

✦ Synopsis

A quantitative method is presented which utilizes differential scanning calorimetry for the determination of sulfathiazole Form I in the presence of sulfathiazole Form 11. Data are included which demonstrate that the method can be utilized to follow the rate of transformation of Form 1 to Form 11. The kinetics for this transition have been described as being somewhat analogous to diffusion-controlled crystal growth from solution. An activation energy of 56 kcal./mole was calculated for the system. This value was in agreement with the activation energy obtained using a differential thermal method.

Keyphrases 0 Sulfathiazole Form I-quantitative method for determining Form I in presence of Form 11, kinetics of polymorphic transformation, differential scanning calorimetry 0 Transformation kinetics-sulfathiazole Form I and Form 11, quantitative differential scanning calorimetric method 0 Differential scanning calorimetrydetermination of polymorphic transformation of sulfathiazole Form I in presence of Form 11, kinetics