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Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method

โœ Scribed by Seiji Miyauchi; Yuichi Sugiyama; Yasufumi Sawada; Kaname Morita; Tatsuji Iga; Manabu Hanano

Book ID
112473852
Publisher
Springer
Year
1987
Tongue
English
Weight
760 KB
Volume
15
Category
Article
ISSN
1573-8744

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Comparative hepatic transport of desglyc
Comparative hepatic transport of desglycylated and cyclic metabolites of rilmazafone in rats: Analysis by multiple indicator dilution method
โœ Noriyuki Muranushi; Seiji Miyauchi; Hiroshi Suzuki; Yuichi Sugiyama; Manabu Hana ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 573 KB

Rilmazafone (RZ) is an orally active sleep inducer which can be activated to its cyclic form (Ml) via the labile desglycylated metabolite (DG). In this scheme, RZ is exclusively metabolized to DG and M1 by aminopeptidases in the small intestine. The concentration of M1 in the systemic plasma after o