Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: Analysis by multiple indicator dilution method

Comparative hepatic transport of desglyc

Comparative hepatic transport of desglycylated and cyclic metabolites of rilmazafone in rats: Analysis by multiple indicator dilution method

✍ Noriyuki Muranushi; Seiji Miyauchi; Hiroshi Suzuki; Yuichi Sugiyama; Manabu Hana 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 573 KB

Rilmazafone (RZ) is an orally active sleep inducer which can be activated to its cyclic form (Ml) via the labile desglycylated metabolite (DG). In this scheme, RZ is exclusively metabolized to DG and M1 by aminopeptidases in the small intestine. The concentration of M1 in the systemic plasma after o