The dynamic method originally developed for studying the capacity-limited kinetics of the cholecystographic agents iodoxamic acid and iopanoic acid was applied to study the in vivo interactions of these two compounds following coadminstration in the monkey. Results indicate that these interactions a
Kinetics of drug-drug interactions in sheep: Tolbutamide and sulfadimethoxine
β Scribed by J. J. Thiessen; M. Rowland
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 887 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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The kinetics of drug transfer from a buffered aqueous phase (compartment A) through a lipid phase (compartment B ) to another aqueous buffered phase (compartment C) are reported. These kinetics are obtained from an in vifm model system which in important respects mimics drug transfer during the abso
## Abstract Although drugβprotein interactions have been shown to be important in the transport of drugs into and through the eye, ageβrelated differences in ocular drugβprotein binding have not been explored. This study was designed to investigate protein binding characteristics of pilocarpine and