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Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with congestive heart failure

โœ Scribed by Cook, Jack A; Smith, David E; Cornish, Laura A; Tankanow, Roberta M; Nicklas, John M; Hyneck, Martha L


Book ID
109844403
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
1014 KB
Volume
44
Category
Article
ISSN
0009-9236

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Metabolism of the diuretic bumetanide in
โœ M. R. Howlett; G. G. Skellern; W. H. R. Auld; W. R. Murdoch ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer ๐ŸŒ English โš– 351 KB

The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the d