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Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment

✍ Scribed by M. R. Howlett; G. G. Skellern; W. H. R. Auld; W. R. Murdoch

Publisher: Springer
Year: 1990
Tongue: English
Weight: 351 KB
Volume: 38
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00278586

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✦ Synopsis

The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.

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