Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E
β Scribed by Vales-Gomez, M.
- Book ID
- 111746085
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 458 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0261-4189
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## Abstract A subset of CD8^+^ Tβcells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8^+^ Tβcells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expres
The HLA-E class Ib molecule constitutes a major ligand for the lectin-like CD94/NKG2 natural killer (NK) cell receptors. Specific HLA class I leader sequence-derived nonapeptides bind to endogenous HLA-E molecules in the HLA-defective cell line 721.221, inducing HLA-E surface expression, and promote