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Clinical Significance of the HLA-E and CD94/NKG2 Interaction

✍ Scribed by Milena Iwaszko; Katarzyna Bogunia-Kubik


Book ID
105751224
Publisher
Springer
Year
2011
Tongue
English
Weight
547 KB
Volume
59
Category
Article
ISSN
0004-069X

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HLA-E-bound peptides influence recogniti
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The HLA-E class Ib molecule constitutes a major ligand for the lectin-like CD94/NKG2 natural killer (NK) cell receptors. Specific HLA class I leader sequence-derived nonapeptides bind to endogenous HLA-E molecules in the HLA-defective cell line 721.221, inducing HLA-E surface expression, and promote