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Kinetics and dynamics of disopyramide and its dealkylated metabolite in healthy subjects

✍ Scribed by Chiang, Wen-Teh; von Bahr, Christer; Calissendorff, Berit; Dahlqvist, Rune; Emilsson, Håkan; Magnusson, Anita; Schenck-Gustafsson, Karin

Book ID
109843638
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
671 KB
Volume
38
Category
Article
ISSN
0009-9236

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Comparative class 1 electrophysiologic and anticholinergic effects of disopyramide and its main metabolite (mono-N-dealkylated disopyramide) in healthy humans
✍ Lennart Bergfeldt; Karin Schenck-Gustafsson; Rune Dahlqvist 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 860 KB

During steady-state treatment with disopyramide, its main and active metabolite, mono-N-dealkylated disopyramide, was reported to reach concentrations that were equal to or higher than the parent drug in 25% of 70 evaluated patients. This metabolite has been found to have a more pronounced anticholi